Biopsy - Quiz

1. Who introduced the word 'biopsie' to the medical community in 1879?

A) Marie Curie
B) Ernest Besnier
C) Louis Pasteur
D) Abulcasis

2. What does the Greek word 'bios' mean?

A) Tissue
B) Life
C) Death
D) Sight

3. Which ancient physician developed one of the earliest diagnostic biopsies?

A) Avicenna
B) Galen
C) Hippocrates
D) Abulcasis

4. What is an excisional biopsy?

A) A blood test for cancer
B) Removal of a small cell cluster
C) A scan of the tumor site
D) Removal of an entire lump or suspicious area

5. What is examined in a biopsy specimen to see if the disease has spread beyond the biopsied area?

A) The entire organ
B) Surgical margin
C) Cell nucleus
D) Blood vessel density

6. What does a 'positive margin' indicate in a biopsy?

A) Disease was found at the edges
B) The biopsy was unsuccessful
C) No further surgery is needed
D) The lesion is benign

7. Which biopsy type does not preserve the histological architecture of the tissue cells?

A) Punch biopsy
B) Shave biopsy
C) Excisional biopsy
D) Fine needle aspiration biopsy

8. What is the primary purpose of a liquid biopsy?

A) To perform a deep tissue incision
B) To detect cancer cells or substances in body fluid
C) To surgically remove a tumor
D) To examine tissue structure under a microscope

9. What is a main advantage of cell-free circulating tumor DNA (cfDNA) assays over CTC assays?

A) They have zero risk of false negatives
B) They can diagnose the site of the tumor
C) There is approximately 100 times more cfDNA than DNA in circulating tumor cells
D) They are cheaper to produce

10. Why are liquid biopsies considered an advantage over tissue biopsies regarding tumor genetics?

A) They provide a better look at tissue architecture
B) They allow for monitoring rapid, dynamic genetic changes
C) They require no specialized laboratory equipment
D) They are always 100% accurate

11. What is a major drawback of liquid biopsies?

A) They are too painful for the patient
B) They cannot be used to diagnose cancer
C) They require surgery
D) They involve high radiation exposure

12. What does 'pathologic staging' involve in a mastectomy specimen?

A) Revealing the extent of cancer spread
B) Testing the patient's blood type
C) Removing the skin surface
D) Checking for bacterial infection

13. Which professionals can perform a biopsy?

A) Medical students
B) Dentists
C) Laboratory technicians
D) Nurses

14. In the context of the text, what is a resection?

A) A needle aspiration of fluid
B) A larger excisional specimen taken by a surgeon to eradicate a known lesion
C) A biopsy that only takes a tiny fragment
D) A blood test for tumor DNA

15. What do liquid biopsies analyze to track tumor progression?

A) Biopsy of bone marrow
B) Circulating tumor cells and cell-free DNA
C) X-ray images of the lungs
D) Tissue density in the liver

16. Which artery is frequently biopsied when vasculitis is suspected?

A) Femoral artery
B) Temporal artery
C) Radial artery
D) Carotid artery

17. What is vital in the diagnosis of Crescentic glomerulonephritis?

A) Immunofluorescence
B) Blood glucose testing
C) MRI imaging
D) Genetic sequencing

18. Which condition involves the accumulation of degraded proteins in body tissues?

A) Crohn's disease
B) Vasculitis
C) Amyloidosis
D) Glomerulonephritis

19. Where is a biopsy commonly taken to diagnose amyloidosis?

A) Gingiva
B) Heart
C) Brain
D) Liver

20. Who specializes in diagnosing diseases by examining tissue under a microscope?

A) Radiologist
B) General practitioner
C) Surgeon
D) Pathologist

21. What is done to the biopsy sample at the pathology laboratory to make individual cells more visible?

A) Stained with dyes
B) Exposed to radiation
C) Frozen at extreme temperatures
D) Dissolved in acid

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