Central dogma of molecular biology - Quiz
Central dogma of molecular biology
  • 1. What is RNA replication?
A) The degradation of RNA molecules
B) The copying of one RNA to another
C) The synthesis of DNA from RNA
D) The translation of RNA into protein
  • 2. What are the enzymes that copy RNA to new RNA called?
A) Ribosomal peptide synthetases
B) DNA-dependent RNA polymerases
C) Reverse transcriptases
D) RNA-dependent RNA polymerases
  • 3. Where are RNA-dependent RNA polymerases also found, besides viruses?
A) Only in prokaryotes
B) In many eukaryotes
C) Only in prions
D) Exclusively in bacterial plasmids
  • 4. What role do RNA-dependent RNA polymerases play in eukaryotes?
A) DNA replication
B) Intein excision
C) RNA silencing
D) Nonribosomal peptide synthesis
  • 5. What is RNA editing?
A) The destruction of messenger RNA
B) The conversion of proteins into RNA
C) An RNA sequence being altered by a protein complex and a guide RNA
D) The creation of DNA from a protein template
  • 6. What does the central dogma of molecular biology state about sequential information once it passes from nucleic acid to protein?
A) It must be converted into carbohydrates
B) It is immediately destroyed by enzymes
C) It cannot flow back from protein to nucleic acid
D) It can easily flow back to nucleic acid
  • 7. What is post-translational modification?
A) The replication of prions in host cells
B) The direct translation of proteins back into DNA
C) The synthesis of RNA without a DNA template
D) Editing of protein amino-acid sequences by appropriate enzymes after translation
  • 8. Does post-translational modification involve proteins transferring information to nucleic acid?
A) Only in eukaryotes
B) Only in viruses
C) Yes
D) No
  • 9. What synthesizes nonribosomal peptides?
A) Homing endonucleases
B) RNA-dependent RNA polymerases
C) Nonribosomal peptide synthetases
D) Ribosomes
  • 10. What structural features often differentiate nonribosomal peptides from ribosome-synthesized proteins?
A) Double-stranded nucleic acid backbones
B) Cyclic or branched structures and non-proteinogenic amino acids
C) Lack of any peptide bonds
D) Linear structures and standard amino acids only
  • 11. What is an example of nonribosomal peptides?
A) All ribosomal enzymes
B) Most DNA polymerases
C) Some of the antibiotics
D) Prion proteins
  • 12. What is an intein?
A) A parasitic segment of a protein that is able to excise itself
B) A non-proteinogenic amino acid
C) A type of virus that replicates RNA
D) A guide RNA used in RNA editing
  • 13. What does an intein do as amino acid chains emerge from the ribosome?
A) Replicates the ribosomal RNA
B) Destroys the entire protein backbone
C) Excises itself from the chain and rejoins the remaining portions
D) Converts the protein into a nucleic acid
  • 14. What domain do most inteins contain?
A) An RNA silencing domain
B) A homing endonuclease or HEG domain
C) A prion conformation domain
D) A nonribosomal peptide synthetase domain
  • 15. What does the HEG domain initiate upon contacting an intein-free copy of the parent gene?
A) The synthesis of nonribosomal antibiotics
B) The reversal of the central dogma
C) The DNA double-stranded break repair mechanism
D) The immediate degradation of the host cell
  • 16. What are prions?
A) Nonribosomal peptide synthetases
B) Proteins of particular amino acid sequences in particular conformations
C) Small RNA-dependent polymerases found in eukaryotes
D) Enzymes that edit RNA sequences
  • 17. How do prions propagate themselves in host cells?
A) By excising themselves from protein backbones
B) By copying their own nucleic acid sequences
C) By translating RNA directly into new prions
D) By making conformational changes in other molecules of protein with the same amino acid sequence
  • 18. What is the information flow in some types of prion in fungi?
A) Protein → Nucleic acid
B) RNA → DNA → Protein
C) Protein → Protein
D) Nucleic acid → Protein → Nucleic acid
  • 19. Which scientists argued that prion-mediated inheritance violates the central dogma?
A) Rosalind Ridley
B) Watson and Crick
C) Not mentioned in the text
D) Alain E. Bussard and Eugene Koonin
  • 20. What did Rosalind Ridley write regarding the prion hypothesis and the central dogma?
A) The prion hypothesis is not heretical to the central dogma because it does not claim that proteins replicate
B) Proteins are capable of manufacturing nucleic acid sequences
C) The prion hypothesis completely destroys the central dogma by proving protein replication
D) Prions prove that information flows backward from proteins to DNA
  • 21. Who first stated the central dogma in 1957?
A) Francis Crick
B) James Watson
C) Gregor Mendel
D) Rosalind Franklin
  • 22. In what year was Francis Crick's original statement of the central dogma published?
A) 1965
B) 1955
C) 1970
D) 1958
  • 23. In what year was Crick's Nature paper re-stating the central dogma published?
A) 1980
B) 1958
C) 1965
D) 1970
  • 24. Who published the popular but incorrect second version of the central dogma?
A) Watson and Crick
B) Francis Crick
C) James Watson
D) Gregor Mendel
  • 25. In what year was James Watson's first edition of The Molecular Biology of the Gene published?
A) 1970
B) 1958
C) 1965
D) 1975
  • 26. Between Crick's and Watson's versions of the central dogma, which one remains valid today?
A) Neither remains valid
B) Crick's original version
C) Both are equally valid
D) Watson's version
  • 27. What type of polymers are DNA, RNA, and polypeptides?
A) Branched homopolymers
B) Circular lipids
C) Cross-linked polysaccharides
D) Linear heteropolymers
  • 28. In linear heteropolymers, each monomer is connected to at most how many other monomers?
A) Four
B) Two
C) One
D) Three
  • 29. How are the transfers of information from one biopolymer to another described?
A) Random and spontaneous
B) Inconsistent and unstable
C) Faithful, deterministic transfers
D) Chaotic and reversible
  • 30. In groups of how many are proteins encoded?
A) Four
B) Three
C) Two
D) One
  • 31. What are groups of three bases encoding proteins called?
A) Codons
B) Polymers
C) Monomers
D) Templates
  • 32. Which lifeforms or structures are specifically noted as using different translations from the standard codon table?
A) Somatic cells
B) Human mitochondria
C) Plant chloroplasts
D) Bacterial ribosomes
  • 33. What complex group of proteins performs DNA replication?
A) RNA polymerase
B) Transcription factors
C) Ribosomes
D) The replisome
  • 34. During DNA replication, information is copied from the parent strand to which strand?
A) Complementary daughter strand
B) Polypeptide chain
C) Template mRNA strand
D) Pre-mRNA transcript
  • 35. What is the process by which information in a section of DNA is replicated into mRNA called?
A) Replication
B) Splicing
C) Translation
D) Transcription
  • 36. What is the primary transcript called in eukaryotic cells?
A) Complementary DNA
B) Pre-mRNA
C) Polypeptide
D) Mature mRNA
  • 37. What process follows the addition of the 5' cap and poly-A tail to pre-mRNA?
A) Translation
B) Splicing
C) Duplication
D) Replication
  • 38. Where does translation occur for mature mRNA?
A) Within the endoplasmic reticulum
B) Inside the cell nucleus
C) At a ribosome
D) At the Golgi apparatus
  • 39. Where is the site of translation in eukaryotic cells?
A) The nuclear pore
B) The nucleolus
C) The cell nucleus
D) The cytoplasm
  • 40. What is the usual initiator codon that begins translation?
A) UAG
B) UAA
C) UGA
D) AUG
  • 41. What does the acronym AUG stand for in the text?
A) Adenine-uracil-cytosine
B) Alanine-uracil-glycine
C) Adenine-uracil-guanine
D) Adenine-thymine-guanine
  • 42. Which of the following is a stop codon that ends translation?
A) UAA
B) UCA
C) AUG
D) GUA
  • 43. Which triplet can also serve as a stop codon?
A) MET
B) UGA
C) AUG
D) ACC
  • 44. Which of the following is listed in the text as a stop codon?
A) AUG
B) ACU
C) UAG
D) GUU
  • 45. What are the inside 'discarded' sections called when some proteins excise internal segments?
A) Retroviruses
B) Inteins
C) Codons
D) Cofactors
  • 46. What is the family of enzymes involved in reverse transcription called?
A) Initiation factors
B) Elongation factors
C) Chaperone proteins
D) Reverse Transcriptase
  • 47. Who pointed out to Crick that he did not understand the correct use of the word dogma?
A) August Weismann
B) Albert Einstein
C) Jacques Monod
D) Horace Freeland Judson
  • 48. How did Crick view religious beliefs?
A) Without foundation
B) As experimentally proven
C) As central dogma
D) As absolute truths
  • 49. What kind of support did Crick's central dogma have at the time he named it?
A) Little direct experimental support
B) Universal acceptance
C) No theoretical backing
D) Extensive experimental support
  • 50. Who recorded Crick's explanation of the word dogma in 'The Eighth Day of Creation'?
A) Horace Freeland Judson
B) August Weismann
C) Francis Crick
D) Jacques Monod
  • 51. How did Crick describe the word dogma in his interview with Judson?
A) A religious law
B) A proven fact
C) A catch phrase
D) A sacred truth
  • 52. Who proposed the Weismann barrier?
A) August Weismann
B) Jacques Monod
C) Horace Freeland Judson
D) Francis Crick
  • 53. In what year was the Weismann barrier proposed?
A) 1953
B) 1900
C) 1882
D) 1892
  • 54. How are germ cell lineages described in the context of the Weismann barrier?
A) Immortal
B) Temporary
C) Somatic
D) Disposable
  • 55. How are somatic cells described in the context of the Weismann barrier?
A) Permanent
B) Disposable
C) Germline
D) Immortal
  • 56. In what terms was the Weismann barrier's view of life expressed?
A) Religious terms
B) Non-molecular terms
C) Molecular terms
D) Quantum terms
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