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Central dogma of molecular biology - Quiz
Contributed by: Blake
  • 1. What is RNA replication?
A) The copying of one RNA to another
B) The degradation of RNA molecules
C) The synthesis of DNA from RNA
D) The translation of RNA into protein
  • 2. What are the enzymes that copy RNA to new RNA called?
A) Reverse transcriptases
B) Ribosomal peptide synthetases
C) DNA-dependent RNA polymerases
D) RNA-dependent RNA polymerases
  • 3. Where are RNA-dependent RNA polymerases also found, besides viruses?
A) In many eukaryotes
B) Only in prokaryotes
C) Only in prions
D) Exclusively in bacterial plasmids
  • 4. What role do RNA-dependent RNA polymerases play in eukaryotes?
A) Nonribosomal peptide synthesis
B) Intein excision
C) DNA replication
D) RNA silencing
  • 5. What is RNA editing?
A) The conversion of proteins into RNA
B) The creation of DNA from a protein template
C) An RNA sequence being altered by a protein complex and a guide RNA
D) The destruction of messenger RNA
  • 6. What does the central dogma of molecular biology state about sequential information once it passes from nucleic acid to protein?
A) It cannot flow back from protein to nucleic acid
B) It is immediately destroyed by enzymes
C) It must be converted into carbohydrates
D) It can easily flow back to nucleic acid
  • 7. What is post-translational modification?
A) The replication of prions in host cells
B) The direct translation of proteins back into DNA
C) The synthesis of RNA without a DNA template
D) Editing of protein amino-acid sequences by appropriate enzymes after translation
  • 8. Does post-translational modification involve proteins transferring information to nucleic acid?
A) Yes
B) Only in viruses
C) Only in eukaryotes
D) No
  • 9. What synthesizes nonribosomal peptides?
A) Ribosomes
B) Nonribosomal peptide synthetases
C) Homing endonucleases
D) RNA-dependent RNA polymerases
  • 10. What structural features often differentiate nonribosomal peptides from ribosome-synthesized proteins?
A) Cyclic or branched structures and non-proteinogenic amino acids
B) Double-stranded nucleic acid backbones
C) Linear structures and standard amino acids only
D) Lack of any peptide bonds
  • 11. What is an example of nonribosomal peptides?
A) Prion proteins
B) Most DNA polymerases
C) Some of the antibiotics
D) All ribosomal enzymes
  • 12. What is an intein?
A) A parasitic segment of a protein that is able to excise itself
B) A non-proteinogenic amino acid
C) A type of virus that replicates RNA
D) A guide RNA used in RNA editing
  • 13. What does an intein do as amino acid chains emerge from the ribosome?
A) Destroys the entire protein backbone
B) Excises itself from the chain and rejoins the remaining portions
C) Converts the protein into a nucleic acid
D) Replicates the ribosomal RNA
  • 14. What domain do most inteins contain?
A) A nonribosomal peptide synthetase domain
B) An RNA silencing domain
C) A prion conformation domain
D) A homing endonuclease or HEG domain
  • 15. What does the HEG domain initiate upon contacting an intein-free copy of the parent gene?
A) The DNA double-stranded break repair mechanism
B) The reversal of the central dogma
C) The immediate degradation of the host cell
D) The synthesis of nonribosomal antibiotics
  • 16. What are prions?
A) Small RNA-dependent polymerases found in eukaryotes
B) Nonribosomal peptide synthetases
C) Proteins of particular amino acid sequences in particular conformations
D) Enzymes that edit RNA sequences
  • 17. How do prions propagate themselves in host cells?
A) By copying their own nucleic acid sequences
B) By translating RNA directly into new prions
C) By making conformational changes in other molecules of protein with the same amino acid sequence
D) By excising themselves from protein backbones
  • 18. What is the information flow in some types of prion in fungi?
A) Nucleic acid → Protein → Nucleic acid
B) Protein → Nucleic acid
C) Protein → Protein
D) RNA → DNA → Protein
  • 19. Which scientists argued that prion-mediated inheritance violates the central dogma?
A) Alain E. Bussard and Eugene Koonin
B) Rosalind Ridley
C) Not mentioned in the text
D) Watson and Crick
  • 20. What did Rosalind Ridley write regarding the prion hypothesis and the central dogma?
A) The prion hypothesis is not heretical to the central dogma because it does not claim that proteins replicate
B) Proteins are capable of manufacturing nucleic acid sequences
C) Prions prove that information flows backward from proteins to DNA
D) The prion hypothesis completely destroys the central dogma by proving protein replication
  • 21. Who first stated the central dogma in 1957?
A) Francis Crick
B) James Watson
C) Rosalind Franklin
D) Gregor Mendel
  • 22. In what year was Francis Crick's original statement of the central dogma published?
A) 1965
B) 1958
C) 1970
D) 1955
  • 23. In what year was Crick's Nature paper re-stating the central dogma published?
A) 1970
B) 1958
C) 1965
D) 1980
  • 24. Who published the popular but incorrect second version of the central dogma?
A) Watson and Crick
B) Gregor Mendel
C) James Watson
D) Francis Crick
  • 25. In what year was James Watson's first edition of The Molecular Biology of the Gene published?
A) 1965
B) 1975
C) 1958
D) 1970
  • 26. Between Crick's and Watson's versions of the central dogma, which one remains valid today?
A) Neither remains valid
B) Crick's original version
C) Watson's version
D) Both are equally valid
  • 27. What type of polymers are DNA, RNA, and polypeptides?
A) Branched homopolymers
B) Cross-linked polysaccharides
C) Circular lipids
D) Linear heteropolymers
  • 28. In linear heteropolymers, each monomer is connected to at most how many other monomers?
A) Three
B) Four
C) Two
D) One
  • 29. How are the transfers of information from one biopolymer to another described?
A) Random and spontaneous
B) Faithful, deterministic transfers
C) Chaotic and reversible
D) Inconsistent and unstable
  • 30. In groups of how many are proteins encoded?
A) Four
B) One
C) Three
D) Two
  • 31. What are groups of three bases encoding proteins called?
A) Monomers
B) Templates
C) Polymers
D) Codons
  • 32. Which lifeforms or structures are specifically noted as using different translations from the standard codon table?
A) Plant chloroplasts
B) Somatic cells
C) Bacterial ribosomes
D) Human mitochondria
  • 33. What complex group of proteins performs DNA replication?
A) Transcription factors
B) Ribosomes
C) The replisome
D) RNA polymerase
  • 34. During DNA replication, information is copied from the parent strand to which strand?
A) Complementary daughter strand
B) Template mRNA strand
C) Pre-mRNA transcript
D) Polypeptide chain
  • 35. What is the process by which information in a section of DNA is replicated into mRNA called?
A) Transcription
B) Replication
C) Splicing
D) Translation
  • 36. What is the primary transcript called in eukaryotic cells?
A) Mature mRNA
B) Complementary DNA
C) Pre-mRNA
D) Polypeptide
  • 37. What process follows the addition of the 5' cap and poly-A tail to pre-mRNA?
A) Translation
B) Splicing
C) Duplication
D) Replication
  • 38. Where does translation occur for mature mRNA?
A) At a ribosome
B) At the Golgi apparatus
C) Inside the cell nucleus
D) Within the endoplasmic reticulum
  • 39. Where is the site of translation in eukaryotic cells?
A) The nuclear pore
B) The cell nucleus
C) The nucleolus
D) The cytoplasm
  • 40. What is the usual initiator codon that begins translation?
A) AUG
B) UGA
C) UAG
D) UAA
  • 41. What does the acronym AUG stand for in the text?
A) Adenine-thymine-guanine
B) Adenine-uracil-cytosine
C) Alanine-uracil-glycine
D) Adenine-uracil-guanine
  • 42. Which of the following is a stop codon that ends translation?
A) AUG
B) GUA
C) UAA
D) UCA
  • 43. Which triplet can also serve as a stop codon?
A) AUG
B) ACC
C) MET
D) UGA
  • 44. Which of the following is listed in the text as a stop codon?
A) UAG
B) ACU
C) GUU
D) AUG
  • 45. What are the inside 'discarded' sections called when some proteins excise internal segments?
A) Codons
B) Retroviruses
C) Inteins
D) Cofactors
  • 46. What is the family of enzymes involved in reverse transcription called?
A) Elongation factors
B) Initiation factors
C) Chaperone proteins
D) Reverse Transcriptase
  • 47. Who pointed out to Crick that he did not understand the correct use of the word dogma?
A) Albert Einstein
B) August Weismann
C) Jacques Monod
D) Horace Freeland Judson
  • 48. How did Crick view religious beliefs?
A) As central dogma
B) As absolute truths
C) Without foundation
D) As experimentally proven
  • 49. What kind of support did Crick's central dogma have at the time he named it?
A) Universal acceptance
B) Extensive experimental support
C) Little direct experimental support
D) No theoretical backing
  • 50. Who recorded Crick's explanation of the word dogma in 'The Eighth Day of Creation'?
A) Horace Freeland Judson
B) Jacques Monod
C) August Weismann
D) Francis Crick
  • 51. How did Crick describe the word dogma in his interview with Judson?
A) A catch phrase
B) A religious law
C) A proven fact
D) A sacred truth
  • 52. Who proposed the Weismann barrier?
A) Francis Crick
B) August Weismann
C) Jacques Monod
D) Horace Freeland Judson
  • 53. In what year was the Weismann barrier proposed?
A) 1882
B) 1953
C) 1892
D) 1900
  • 54. How are germ cell lineages described in the context of the Weismann barrier?
A) Somatic
B) Temporary
C) Immortal
D) Disposable
  • 55. How are somatic cells described in the context of the Weismann barrier?
A) Immortal
B) Germline
C) Permanent
D) Disposable
  • 56. In what terms was the Weismann barrier's view of life expressed?
A) Non-molecular terms
B) Quantum terms
C) Molecular terms
D) Religious terms
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