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Epidermis - Quiz
Contributed by: Chadwick
  • 1. When does epidermal organogenesis begin?
A) After birth
B) Before neurulation
C) During the formation of the stratum corneum
D) After neurulation
  • 2. What is the initial structure of the epidermis in most vertebrates?
A) Cornified
B) Two-layered
C) Three-layered
D) One-layered
  • 3. What is the temporary outer layer of the early epidermis called?
A) Stratum germinativum
B) Stratum corneum
C) Embryonic periderm
D) Stratum spinosum
  • 4. What is another name for the inner basal layer of the epidermis?
A) Stratum germinativum
B) Embryonic periderm
C) Malpighian layer
D) Stratum granulosum
  • 5. The stratum germinativum divides to form which outer layer?
A) Stratum corneum
B) Stratum spinosum
C) Stratum granulosum
D) Embryonic periderm
  • 6. What are the basal and spinous layers together called?
A) Cornified layer
B) Malpighian layer
C) Granular layer
D) Periderm
  • 7. Whose name is associated with the Malpighian layers?
A) Gregor Mendel
B) Marcello Malpighi
C) Louis Pasteur
D) Robert Hooke
  • 8. The Malpighian layers divide to form which superficial layer?
A) Stratum granulosum
B) Embryonic periderm
C) Dermal layer
D) Stratum corneum
  • 9. Do cells in the stratum granulosum divide?
A) Only after birth
B) No
C) Only during stress
D) Yes
  • 10. What do cells in the stratum granulosum form from keratin granules?
A) Keratinocytes
B) Fibroblasts
C) Periderm cells
D) Glucocorticoids
  • 11. What is the outermost epidermal layer called?
A) Stratum germinativum
B) Stratum corneum
C) Stratum granulosum
D) Stratum spinosum
  • 12. What shape do cells become in the cornified layer?
A) Round spheres
B) Elongated fibers
C) Cube-shaped
D) Flattened sacks
  • 13. Where are the nuclei located in the cells of the stratum corneum?
A) In the exact center
B) Scattered throughout
C) At one end of the cell
D) They have no nuclei
  • 14. How many milligrams of skin flakes are shed every hour?
A) 10 – 20 milligrams
B) 1 – 5 grams
C) 30 – 90 milligrams
D) 100 – 200 milligrams
  • 15. How many grams of skin flakes are shed per day?
A) 0.01 - 0.05 grams
B) 0.720 - 2.16 grams
C) 5.0 - 10.0 grams
D) 20.0 - 50.0 grams
  • 16. What type of growth factor is Transforming growth factor Alpha (TGFα)?
A) Autocrine growth factor
B) Paracrine growth factor
C) Inhibitory growth factor
D) Endocrine growth factor
  • 17. What is the function of TGFα in basal cells?
A) Stop cell division
B) Produce keratin granules
C) Stimulate their own division
D) Regulate dermal fibroblasts
  • 18. What is another name for Keratinocyte growth factor?
A) TGFβ
B) TGFα
C) FGF7
D) FGF2
  • 19. What type of growth factor is KGF?
A) Autocrine growth factor
B) Hormonal factor
C) Paracrine growth factor
D) Endocrine growth factor
  • 20. Where is KGF produced?
A) Stratum corneum
B) Stratum granulosum
C) Embryonic periderm
D) Underlying dermal fibroblasts
  • 21. What is regulated by KGF?
A) Shedding of skin flakes
B) Proliferation of basal cells
C) Production of sweat
D) Hydration of the stratum corneum
  • 22. What gives the epidermis its mechanical strength?
A) Autocrine growth factors
B) Loose fat deposits
C) High water content
D) Cytoskeletal proteins linked to cell-cell junctions
  • 23. What inhibits the passage of external chemicals into the body?
A) High external humidity
B) Loose cellular junctions
C) Glucocorticoids
D) Highly organized lipids, acids, hydrolytic enzymes, and antimicrobial peptides
  • 24. What combat infection using humoral and cellular constituents in the epidermis?
A) Physical barrier
B) Non-pathogenic microorganisms
C) Chemical barrier
D) Immunologically active barrier
  • 25. What happens to the water content of the stratum corneum towards the surface?
A) It remains constant
B) It drops
C) It increases
D) It fluctuates wildly
  • 26. What approximate pH makes the epidermis hostile to many microorganisms?
A) 5.0
B) 3.0
C) 9.0
D) 7.0
  • 27. How do non-pathogenic microorganisms help defend the epidermis?
A) By breaking down keratinocytes
B) By competing for food and producing inhibitory chemical secretions
C) By increasing skin pH
D) By absorbing UV light
  • 28. What hormone increases during psychological stress to compromise the stratum corneum?
A) Insulin
B) Glucocorticoids
C) Adrenaline
D) Thyroxine
  • 29. What effect does psychological stress have on the barrier function?
A) It has no effect
B) It strengthens it
C) It increases cell division
D) It compromises it
  • 30. What environmental shift can alter stratum corneum hydration and allow pathogen entry?
A) Sudden and large shifts in humidity
B) Gradual temperature drops
C) Exposure to UV light
D) Changes in atmospheric pressure
  • 31. The epidermis provides mechanical resistance against what kind of injury?
A) Bone fractures
B) Minor injury
C) Internal organ failure
D) Severe trauma
  • 32. Oxidative stress protection by the epidermis is primarily against what?
A) X-rays
B) Radio waves
C) UV light
D) Infrared heat
  • 33. What is the outermost of the three major layers that constitute the skin?
A) Epidermis
B) Hypodermis
C) Basement membrane
D) Dermis
  • 34. What is the maximum thickness of the epidermis mentioned in the text?
A) 596.6 μm
B) 1000 μm
C) 31.2 μm
D) 90 μm
  • 35. What type of epithelium is the human epidermis an example of?
A) Simple squamous epithelium
B) Pseudostratified epithelium
C) Stratified squamous epithelium
D) Simple columnar epithelium
  • 36. How does the epidermis primarily receive its nourishment?
A) Diffused oxygen from surrounding air
B) Arterioles and venules
C) Blood capillaries inside the layer
D) Dermal blood vessels via direct contact
  • 37. Which transmembrane proteins form the adherens junctions between epidermal cells?
A) Keratins
B) Corneodesmosomes
C) Cadherins
D) Melanocytes
  • 38. How many layers of anucleated corneocytes typically compose the cornified layer?
A) About 2 layers
B) About 5 layers
C) About 50 layers
D) About 15 layers
  • 39. What separates the epidermis from the underlying dermis?
A) Rete ridges
B) Lamellar bodies
C) Basement membrane
D) Plasma membrane
  • 40. What are epidermal thickenings that extend downward between dermal papillae called?
A) Rete ridges
B) Cadherins
C) Corneodesmosomes
D) Hemidesmosomes
  • 41. What happens to differentiating cells as they delaminate from the basement membrane?
A) They move inward
B) They remain stationary
C) They are displaced outward
D) They divide into stem cells
  • 42. In normal skin, how does the rate of keratinocyte production compare to the rate of loss?
A) Loss exceeds production
B) Production exceeds loss
C) They are completely independent
D) Production equals loss
  • 43. How long does it take to cross the stratum corneum after reaching the top of the stratum granulosum?
A) An additional four weeks
B) About 48 days
C) About two weeks
D) A few hours
  • 44. What mediates keratinocyte differentiation throughout the epidermis?
A) A temperature gradient
B) A calcium gradient
C) A sodium gradient
D) A protein concentration gradient
  • 45. What is considered a key regulator in the formation of epidermal layers?
A) The rate of cell division
B) The calcium gradient
C) The secretion of melanin
D) The shedding of squamous sheets
  • 46. Where does part of the intracellular calcium increase come from?
A) Blood plasma proteins
B) Keratin filaments
C) Extracellular melanin
D) Intracellular stores
  • 47. What type of receptor is suggested to contribute to the rise in intracellular calcium concentration?
A) Extracellular calcium-sensing receptor
B) Voltage-gated potassium receptor
C) Light-sensitive photoreceptor
D) Intracellular sodium receptor
  • 48. What scientific method is used to quantify skin hydration?
A) Biopsy
B) Corneometry
C) Melanometry
D) Keratometry
  • 49. Where are melanosomes originally formed?
A) Stratum corneum
B) Merkel cells
C) Melanocytes
D) Keratinocytes
  • 50. How do Merkel cells intrinsically transform touch in model organisms like mice?
A) Into lipid barriers
B) Into melanin pigments
C) Into chemical gradients
D) Into electrical signals
  • 51. What is acanthosis?
A) Thickening of the stratum corneum only
B) A benign condition simulating squamous cell carcinoma
C) Diffuse epidermal hyperplasia
D) A localized lack of melanocytes
  • 52. What describes acanthosis nigricans?
A) Irregular squamous strands extending down into the dermis
B) A localized thickening of the stratum corneum
C) Multiple white to pinkish papules in the oral cavity
D) A black, poorly defined, velvety hyperpigmented acanthosis
  • 53. What is another name for focal epithelial hyperplasia?
A) Pseudoepitheliomatous hyperplasia
B) Heck's disease
C) Acanthosis nigricans
D) Squamous cell carcinoma
  • 54. What condition closely simulates squamous cell carcinoma?
A) Heck's disease
B) Acanthosis nigricans
C) Diffuse acanthosis
D) Pseudoepitheliomatous hyperplasia
  • 55. Do the numbers of melanocytes vary between different body regions?
A) Only after UV exposure
B) Only in white and Asian skin
C) Yes
D) No
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